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Pentacel vaccine

Pentacel vaccine contains:1

  • The same 5 acellular pertussis antigens found in DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed). Pentacel and DAPTACEL vaccines contain the same pertussis antigens manufactured by the same process, but Pentacel vaccine contains twice as much inactivated PTb and 4 times as much FHAc as DAPTACEL vaccine
  • ActHIB® (Haemophilus b Conjugate Vaccine [Tetanus Toxoid Conjugate])
  • Inactivated Poliovirus Vaccine

Pentacel vaccine is indicated for children 6 weeks through 4 years of age (prior to fifth birthday).1 Pentacel vaccine should be administered during the following visits:2

2 month

  4 month   6 month   15-18 month  

Using a Pentacel vaccine-based schedule through 18 months of age can eliminate as many as 7 injections compared with a schedule using separately administered vaccines.2,3,d


Pentacel vaccine is indicated for active immunization against diphtheria, tetanus, pertussis, poliomyelitis, and invasive disease due to Haemophilus influenzae type b. Pentacel vaccine is approved for use in children 6 weeks through 4 years of age (prior to fifth birthday).

Safety Information

The most common local and systemic adverse reactions to Pentacel vaccine include injection site redness, swelling, and tenderness; fever, fussiness, and crying. Other adverse reactions may occur. Known systemic hypersensitivity reaction to any component of Pentacel vaccine or a life-threatening reaction after previous administration of the vaccine or a vaccine containing the same substances are contraindications to vaccination.

The decision to give Pentacel vaccine should be based on the potential benefits and risks; if Guillain-Barré syndrome has occurred within 6 weeks of receipt of a prior vaccine containing tetanus toxoid; or if adverse events have occurred in temporal relation to receipt of pertussis-containing vaccine. Encephalopathy within 7 days of administration of a previous dose of a pertussis-containing vaccine or a progressive neurologic disorder is a contraindication. Vaccination with Pentacel vaccine may not protect all individuals.

Before administering Pentacel vaccine, please see full Prescribing Information.

CPT®e Code: 90698

a DTaP = Diphtheria, tetanus, and acellular pertussis; IPV = Inactivated poliovirus; Hib = Haemophilus influenzae type b.
b PT = Pertussis toxin detoxified.
c FHA = Filamentous hemagglutinin.
d Injection calculations based on the use of ActHIB vaccine as part of the immunization schedule.
e CPT = Current Procedural Terminology and is a registered trademark of the American Medical Association.

ActHIB vaccine is manufactured by Sanofi Pasteur SA and distributed by Sanofi Pasteur Inc.

DAPTACEL vaccine is manufactured by Sanofi Pasteur Limited and distributed by Sanofi Pasteur Inc.

Pentacel vaccine is manufactured by Sanofi Pasteur Limited and Sanofi Pasteur SA and distributed by Sanofi Pasteur Inc.

References: 1. Pentacel vaccine [Prescribing Information]. Swiftwater, PA: Sanofi Pasteur Inc.; 2008. 2. Centers for Disease Control and Prevention. Recommended immunization schedules for persons aged 0-18 years—United States, 2008. MMWR. 2008;57(1):Q1–Q4. 3. Food and Drug Administration. Pentacel®: DTaP-IPV/Hib Combined (diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and Haemophilus b conjugate [tetanus toxoid conjugate] vaccine). VRBPAC Briefing Document. Accessed April 2, 2008.



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